Source:http://linkedlifedata.com/resource/pubmed/id/20817749
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2011-3-18
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| pubmed:abstractText |
In Western societies a considerable percentage of young people expose themselves to the combination of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') and cannabis. The aim of the present study was to assess the acute effects of co-administration of MDMA and THC (the main psychoactive compound of cannabis) on pharmacokinetics, psychomotor performance, memory and subjective experience over time. We performed a four-way, double blind, randomized, crossover, placebo-controlled study in 16 healthy volunteers (12 male, four female) between the ages of 18 and 27. MDMA (100?mg) was given orally, THC (4, 6, and 6?mg, interval of 90?min) was vaporized and inhaled. THC induced more robust cognitive impairment compared with MDMA, and co-administration did not exacerbate single drug effects on cognitive function. However, co-administration of THC with MDMA increased desired subjective drug effects and drug strength compared with the MDMA condition, which may explain the widespread use of this combination.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
1461-7285
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
25
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
478-89
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| pubmed:meshHeading |
pubmed-meshheading:20817749-Administration, Inhalation,
pubmed-meshheading:20817749-Adult,
pubmed-meshheading:20817749-Cannabis,
pubmed-meshheading:20817749-Cognition,
pubmed-meshheading:20817749-Cross-Over Studies,
pubmed-meshheading:20817749-Double-Blind Method,
pubmed-meshheading:20817749-Drug Interactions,
pubmed-meshheading:20817749-Drug Therapy, Combination,
pubmed-meshheading:20817749-Euphoria,
pubmed-meshheading:20817749-Female,
pubmed-meshheading:20817749-Humans,
pubmed-meshheading:20817749-Male,
pubmed-meshheading:20817749-Memory,
pubmed-meshheading:20817749-N-Methyl-3,4-methylenedioxyamphetamine,
pubmed-meshheading:20817749-Neuropsychological Tests,
pubmed-meshheading:20817749-Placebos,
pubmed-meshheading:20817749-Psychomotor Performance,
pubmed-meshheading:20817749-Tetrahydrocannabinol,
pubmed-meshheading:20817749-Young Adult
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Acute psychomotor, memory and subjective effects of MDMA and THC co-administration over time in healthy volunteers.
|
| pubmed:affiliation |
Donders Institute for Brain, Cognition and Behaviour, Department of Psychiatry, Radboud University Nijmegen Medical Centre, The Netherlands. g.j.h.dumont@psy.umcn.nl
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|