Linked Life Data

20816732

Source:http://linkedlifedata.com/resource/pubmed/id/20816732

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2010-10-11
pubmed:abstractText
Human taste testing is often associated with ethical concerns, organizational and validation issues. Electrochemical sensor array systems, so called electronic tongues, offer an alternative to assess the taste of multi-component liquid formulations. Therefore, it should be investigated how an electronic tongue can be implemented in the rational development of taste masked formulations. Taste masking of bitter tasting quinine hydrochloride (QH) in a liquid formulation was carried out by screening sweetening agents (sucrose, glucose, fructose, mannitol, sucralose, sodium saccharin, acesulfame potassium, and monoammonium glycyrrhizinate), strong and weak cation ion exchange (IE) resins (Amberlite™ IRP69, Amberlite™ IRP88, and Indion 234), and soluble complexing agents (?-, ?-, hydroxypropyl-?-, sulfobutyl ether-?- and ?-cyclodextrin and maltodextrin). Amberlite™ IRP88 showed the best binding capacity for quinine (1.9 g quinine/1 g IE). The addition of sulfobutyl ether-?-cyclodextrin (SBE-?-CD) could significantly reduce the bitter taste of QH (79% reduction of free QH). The SBE-?-CD formulation was further improved by adding sodium saccharin as secondary taste masking agent. It could also be shown that presence of strawberry flavor and the preservative domiphen bromide does not affect evaluation of taste masking efficiency. The introduced stepwise approach was shown to be applicable to rationally develop novel taste masked formulations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1873-3476
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
400
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
114-23
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Rational development of taste masked oral liquids guided by an electronic tongue.
pubmed:affiliation
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany. Katharina.Woertz@uni-duesseldorf.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't