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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-9-6
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pubmed:abstractText |
The insulin-like signaling (ILS) pathway regulates metabolism and is known to modulate adult life span in C. elegans. Altered stress responses and resistance to a wide range of stressors are also associated with changes in ILS and contribute to enhanced longevity. The transcription factors DAF-16 and HSF-1 are key effectors of the longevity phenotype. We demonstrate that increased intrinsic thermotolerance, due to lower ILS, is not dependent on stress-induced transcriptional responses but instead requires active protein translation. Translation profiling experiments reveal genes that are posttranscriptionally regulated in response to altered ILS during heat shock in a DAF-16-dependent manner. Furthermore, several novel proteins are specifically required for ILS effects on thermotolerance. We propose that lowered ILS results in metabolic and physiological changes. These DAF-16-induced changes precondition a translational response under acute stress to modulate survival.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AG025798,
http://linkedlifedata.com/resource/pubmed/grant/AG029631-01A1,
http://linkedlifedata.com/resource/pubmed/grant/AG031337,
http://linkedlifedata.com/resource/pubmed/grant/AG032113,
http://linkedlifedata.com/resource/pubmed/grant/AG21069,
http://linkedlifedata.com/resource/pubmed/grant/AG22868,
http://linkedlifedata.com/resource/pubmed/grant/ES016655,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012423-14,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG021069-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG022868-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG029631-01A1,
http://linkedlifedata.com/resource/pubmed/grant/RL1 ES016655-01,
http://linkedlifedata.com/resource/pubmed/grant/RL1 ES016655-05,
http://linkedlifedata.com/resource/pubmed/grant/UL1 RR024917
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20816092-10590837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20816092-11021802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20816092-11445592,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20816092-8389142,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20816092-9252323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20816092-9353126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20816092-9725835
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DAF-2 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/daf-16 protein, C elegans
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1932-7420
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pubmed:author |
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pubmed:copyrightInfo |
2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
260-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
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