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pubmed-article:20815779pubmed:dateCreated2010-10-14lld:pubmed
pubmed-article:20815779pubmed:abstractTextDespite their being good markers of oxidative stress for clinical use, little is known about ubiquinol-10 (reduced coenzyme Q10) and ubiquinone-10 (oxidized coenzyme Q10) levels in foetuses and their mothers. This study investigates oxidative stress in 10 healthy maternal venous, umbilical arterial and venous bloods after vaginal delivery by measuring ubiquinol-10 and ubiquinone-10 levels. Serum ubiquinol-10 and ubiquinone-10 levels were measured by HPLC with a highly sensitive electrochemical detector. Maternal venous ubiquinol-10 and ubiquinone-10 levels were significantly higher than umbilical arterial and venous levels (all p < 0.001). However, the ubiquinone-10/total coenzyme Q10 (CoQ10) ratio, which reflects the redox status, was significantly higher in umbilical arterial and umbilical venous blood compared to maternal venous blood (all p < 0.001). The ubiquinone-10/total CoQ10 ratio was higher in umbilical arterial than in umbilical venous blood (p < 0.01). The present study demonstrated that foetuses were under higher oxidative stress than their mothers.lld:pubmed
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pubmed-article:20815779pubmed:authorpubmed-author:WatanabeEtsuk...lld:pubmed
pubmed-article:20815779pubmed:authorpubmed-author:MurashimaSach...lld:pubmed
pubmed-article:20815779pubmed:authorpubmed-author:HasumiYokoYlld:pubmed
pubmed-article:20815779pubmed:authorpubmed-author:HarunaMegumiMlld:pubmed
pubmed-article:20815779pubmed:authorpubmed-author:SekineKyouich...lld:pubmed
pubmed-article:20815779pubmed:authorpubmed-author:TanizakiTakas...lld:pubmed
pubmed-article:20815779pubmed:authorpubmed-author:MatsuzakiMasa...lld:pubmed
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pubmed-article:20815779pubmed:year2010lld:pubmed
pubmed-article:20815779pubmed:articleTitleUbiquinol-10 and ubiquinone-10 levels in umbilical cord blood of healthy foetuses and the venous blood of their mothers.lld:pubmed
pubmed-article:20815779pubmed:affiliationDepartment of Midwifery and Women's Health, Division of Health Sciences & Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. msumi-tky@umin.ac.jplld:pubmed
pubmed-article:20815779pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20815779pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed