|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004461,
umls-concept:C0026336,
umls-concept:C0026769,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0231170,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1517945,
umls-concept:C1522424,
umls-concept:C1524003,
umls-concept:C1706438,
umls-concept:C2698600
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|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2010-9-3
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|
pubmed:abstractText |
The objective of this study was to test the hypothesis that CD8+ T cells directly mediate motor disability and axon injury in the demyelinated central nervous system. We have previously observed that genetic deletion of the CD8+ T cell effector molecule perforin leads to preservation of motor function and preservation of spinal axons in chronically demyelinated mice.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1932-6203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
5
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
e12478
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pubmed:meshHeading |
pubmed-meshheading:20814579-Animals,
pubmed-meshheading:20814579-Axons,
pubmed-meshheading:20814579-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20814579-Demyelinating Diseases,
pubmed-meshheading:20814579-Disease Models, Animal,
pubmed-meshheading:20814579-Female,
pubmed-meshheading:20814579-Gene Expression Regulation,
pubmed-meshheading:20814579-Histocompatibility Antigens,
pubmed-meshheading:20814579-Leukocytes,
pubmed-meshheading:20814579-Male,
pubmed-meshheading:20814579-Mice,
pubmed-meshheading:20814579-Motor Activity,
pubmed-meshheading:20814579-Motor Cortex,
pubmed-meshheading:20814579-Multiple Sclerosis,
pubmed-meshheading:20814579-Perforin,
pubmed-meshheading:20814579-Spinal Cord
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|
pubmed:year |
2010
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|
pubmed:articleTitle |
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis.
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pubmed:affiliation |
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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