Linked Life Data

20814416

Source:http://linkedlifedata.com/resource/pubmed/id/20814416

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-31
pubmed:abstractText
Adiponectin and resistin's possible roles in weight regulation have received little attention. We tested the hypothesis that adipokine levels predict future weight gain in women in the Nurses' Health Study. Among women who provided blood samples in 1990, we studied 1,063 women who did not develop diabetes ("healthy") and 984 women who subsequently developed diabetes. Total and high-molecular-weight (HMW) adiponectin and resistin levels were measured using enzyme-linked immunosorbent assay. Women who did not developed diabetes had a mean BMI of 26.3 ± 6.0 kg/m(2) at baseline and gained 2.0 ± 6.1 kg over 4 years. Women who developed diabetes had a mean BMI of 30.1 ± 5.4 kg/m(2) at baseline, and gained 2.4 ± 7.1 kg over 4 years. In women who did not developed diabetes, higher baseline levels of total and HMW adiponectin were associated with significantly greater weight gain after adjustment for age, BMI, physical activity, diet, and other covariates: women in the highest quintile of total adiponectin gained 3.18 kg compared to women in the lowest quintile who gained 0.80 kg (fully adjusted; P for trend <0.0001). Adiponectin was not significantly associated with weight gain in women who subsequently developed diabetes. Resistin levels were not associated with weight gain in either women who did or did not develop diabetes during the follow-up. We conclude that elevated adiponectin levels are associated with higher weight gain in healthy women, independent of confounding risk factors. High adiponectin production by adipocytes might be a sign of "healthy" adipose tissue with further capacity to store fat.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/DK 081913, http://linkedlifedata.com/resource/pubmed/grant/DK58785, http://linkedlifedata.com/resource/pubmed/grant/DK58845, http://linkedlifedata.com/resource/pubmed/grant/DK79929, http://linkedlifedata.com/resource/pubmed/grant/K24 DK080140, http://linkedlifedata.com/resource/pubmed/grant/K24 DK080140-01, http://linkedlifedata.com/resource/pubmed/grant/K24 DK080140-05, http://linkedlifedata.com/resource/pubmed/grant/K24 DK081913-02, http://linkedlifedata.com/resource/pubmed/grant/K24 DK081913-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DK058785-02S1, http://linkedlifedata.com/resource/pubmed/grant/R01 DK058845-09, http://linkedlifedata.com/resource/pubmed/grant/R01 DK079929-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DK079929-04
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1930-7381
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-15
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Higher adiponectin levels predict greater weight gain in healthy women in the Nurses' Health Study.
pubmed:affiliation
General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural