Linked Life Data

20813632

Source:http://linkedlifedata.com/resource/pubmed/id/20813632

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-4
pubmed:abstractText
Studying the inner ear microvascular dynamics is extremely important to understand the cochlear function and to further advance the diagnosis, prevention, and treatment of many otologic disorders. However, there is currently no effective imaging tool available that is able to access the blood flow within the intact cochlea. In this paper, we report the use of an ultrahigh sensitive optical micro-angiography (UHS-OMAG) imaging system to image 3-D microvascular perfusion within the intact cochlea in living mice. The UHS-OMAG image system used in this study is based on spectral domain optical coherence tomography, which uses a broadband light source centered at 1300 nm with an imaging rate of 47[Formula: see text] 000 A-scans/s, capable of acquiring high-resolution B scans at 300 frames/s. The technique is sensitive enough to image very slow blood flow velocities, such as those found in capillary networks. The 3-D imaging acquisition time for a whole cochlea is  ? 4.1 s. We demonstrate that volumetric reconstruction of microvascular flow obtained by UHS-OMAG provides a comprehensive perfusion map of several regions of the cochlea, including the otic capsule, the stria vascularis of the apical and middle turns and the radiating arterioles that emanate from the modiolus.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/KL2RR024141, http://linkedlifedata.com/resource/pubmed/grant/R01 DC000105, http://linkedlifedata.com/resource/pubmed/grant/R01 DC000105-35, http://linkedlifedata.com/resource/pubmed/grant/R01 DC000105-36, http://linkedlifedata.com/resource/pubmed/grant/R01 DC010201-01, http://linkedlifedata.com/resource/pubmed/grant/R01 DC010201-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DC010201-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DC010399-01, http://linkedlifedata.com/resource/pubmed/grant/R01 DC010399-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DC010399-03, http://linkedlifedata.com/resource/pubmed/grant/R01DC010201, http://linkedlifedata.com/resource/pubmed/grant/R01DC010399, http://linkedlifedata.com/resource/pubmed/grant/R03DC008888
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1558-0062
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
224-30
pubmed:dateRevised
2011-10-14
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography.
pubmed:affiliation
Biophotonics and Imaging Laboratory, Division of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA. mollysub@bme.ogi.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural