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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-9-13
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pubmed:abstractText |
Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been made in understanding the pathologic mechanism of the disease, the precise orchestration of the early events leading to cyst formation is still unclear. Abnormal cellular proliferation was traditionally considered to be one of the primary irregularities leading to cyst initiation and growth. Consequently, many therapeutic interventions have focused on targeting this abnormal proliferation, and some have even progressed to clinical trials. However, the role of proliferation in cyst development was primarily examined at stages where cysts are already visible in the kidneys and therefore at later stages of disease development.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2369
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23
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pubmed:dateRevised |
2011-3-28
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pubmed:meshHeading |
pubmed-meshheading:20813037-Animals,
pubmed-meshheading:20813037-Cell Division,
pubmed-meshheading:20813037-Disease Progression,
pubmed-meshheading:20813037-Epithelial Cells,
pubmed-meshheading:20813037-Focal Adhesions,
pubmed-meshheading:20813037-Gene Expression Profiling,
pubmed-meshheading:20813037-Gene Expression Regulation, Developmental,
pubmed-meshheading:20813037-Humans,
pubmed-meshheading:20813037-Kidney,
pubmed-meshheading:20813037-Male,
pubmed-meshheading:20813037-Peptide Fragments,
pubmed-meshheading:20813037-Phenotype,
pubmed-meshheading:20813037-Polycystic Kidney, Autosomal Dominant,
pubmed-meshheading:20813037-RNA, Messenger,
pubmed-meshheading:20813037-Rats,
pubmed-meshheading:20813037-Rats, Sprague-Dawley,
pubmed-meshheading:20813037-Rats, Transgenic,
pubmed-meshheading:20813037-Renin-Angiotensin System,
pubmed-meshheading:20813037-TRPP Cation Channels,
pubmed-meshheading:20813037-Wnt Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways.
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pubmed:affiliation |
Department of Biological Sciences, University of Cyprus.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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