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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-9-2
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pubmed:abstractText |
TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequence variation in PSC, as well as functionally characterize detected variants.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:BalschunTobiasT,
pubmed-author:BergquistAnnikaA,
pubmed-author:BeuersUlrichU,
pubmed-author:BobergKirsten MKM,
pubmed-author:ElSharawyAbdouA,
pubmed-author:EllinghausEvaE,
pubmed-author:FrankeAndreA,
pubmed-author:GotthardtDanielD,
pubmed-author:HäussingerDieterD,
pubmed-author:HenckaertsLiesbetL,
pubmed-author:HovJohannes RJR,
pubmed-author:IBSEN Study Group,
pubmed-author:KarlsenTom HTH,
pubmed-author:KeitelVerenaV,
pubmed-author:LaerdahlJon KJK,
pubmed-author:LieBenedicte ABA,
pubmed-author:MankeThomasT,
pubmed-author:MannsMichael PMP,
pubmed-author:MathewChristopher GCG,
pubmed-author:MelumEspenE,
pubmed-author:OnnieClive MCM,
pubmed-author:PonsioenCyriel YCY,
pubmed-author:RunzHeikoH,
pubmed-author:RustChristianC,
pubmed-author:SchrammChristophC,
pubmed-author:SchreiberStefanS,
pubmed-author:SchrumpfErikE,
pubmed-author:SpomerLinaL,
pubmed-author:SterneckMartinaM,
pubmed-author:StiehlAdolfA,
pubmed-author:StokkersPieter C FPC,
pubmed-author:TeufelAndreasA,
pubmed-author:VatnMorten HMH,
pubmed-author:VermeireSeverineS,
pubmed-author:WeersmaRinse KRK,
pubmed-author:WeismüllerTobiasT,
pubmed-author:WijmengaCiscaC
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e12403
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pubmed:meshHeading |
pubmed-meshheading:20811628-Adolescent,
pubmed-meshheading:20811628-Adult,
pubmed-meshheading:20811628-Aged,
pubmed-meshheading:20811628-Amino Acid Sequence,
pubmed-meshheading:20811628-Animals,
pubmed-meshheading:20811628-Cattle,
pubmed-meshheading:20811628-Child,
pubmed-meshheading:20811628-Cholangitis, Sclerosing,
pubmed-meshheading:20811628-Chromosomes, Human, Pair 2,
pubmed-meshheading:20811628-Colitis, Ulcerative,
pubmed-meshheading:20811628-DNA Mutational Analysis,
pubmed-meshheading:20811628-Dogs,
pubmed-meshheading:20811628-Female,
pubmed-meshheading:20811628-Gene Expression Regulation,
pubmed-meshheading:20811628-Humans,
pubmed-meshheading:20811628-Male,
pubmed-meshheading:20811628-Mice,
pubmed-meshheading:20811628-Middle Aged,
pubmed-meshheading:20811628-Models, Molecular,
pubmed-meshheading:20811628-Mutation,
pubmed-meshheading:20811628-Protein Conformation,
pubmed-meshheading:20811628-Receptors, G-Protein-Coupled,
pubmed-meshheading:20811628-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.
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pubmed:affiliation |
Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway. j.e.r.hov@medisin.uio.no
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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