Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12 Pt 1
|
| pubmed:dateCreated |
1991-5-7
|
| pubmed:abstractText |
This study was designed to investigate the effect of propranolol on endothelin (ET)-1-induced increase in cytosolic Ca2+ [( CA2+]i) in cultured vascular smooth muscle cells (VSMCs) obtained from rat aorta. Propranolol (0.01 to 1 mmol/L) reduced the changes in the initial transient and the later sustained phase of [Ca2+]i induced by 100 nmol/L ET-1 as well as 10 mmol/L procaine. The inhibitory action of propranolol on the change in [Ca2+]i induced by ET-1 may be involved in one of the mechanisms of propranolol-induced reduction of vasospasms.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0895-7061
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
936-8
|
| pubmed:dateRevised |
2009-2-24
|
| pubmed:meshHeading |
pubmed-meshheading:2081014-Animals,
pubmed-meshheading:2081014-Calcium,
pubmed-meshheading:2081014-Cells, Cultured,
pubmed-meshheading:2081014-Coronary Vasospasm,
pubmed-meshheading:2081014-Cytosol,
pubmed-meshheading:2081014-Endothelins,
pubmed-meshheading:2081014-Muscle, Smooth, Vascular,
pubmed-meshheading:2081014-Procaine,
pubmed-meshheading:2081014-Propranolol
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Effect of propranolol on endothelin-induced increase in cytosolic free calcium.
|
| pubmed:affiliation |
First Department of Internal Medicine, Osaka City University Medical School, Japan.
|
| pubmed:publicationType |
Journal Article
|