|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2010-9-17
|
|
pubmed:abstractText |
Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (DPYD).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1471-2407
|
|
pubmed:author |
pubmed-author:CostaVera LVL,
pubmed-author:DiasPaula CPC,
pubmed-author:HenriqueRuiR,
pubmed-author:JerónimoCarmenC,
pubmed-author:MachadoManuelaM,
pubmed-author:PinheiroManuelaM,
pubmed-author:Ramalho-CarvalhoJoãoJ,
pubmed-author:RodriguesAngeloA,
pubmed-author:Savva-BordaloJoanaJ,
pubmed-author:TeixeiraManuel RMR,
pubmed-author:VeigaIsabelI
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
470
|
|
pubmed:meshHeading |
pubmed-meshheading:20809970-Adenocarcinoma,
pubmed-meshheading:20809970-Adult,
pubmed-meshheading:20809970-Aged,
pubmed-meshheading:20809970-Anemia,
pubmed-meshheading:20809970-Antimetabolites, Antineoplastic,
pubmed-meshheading:20809970-Carcinoma, Squamous Cell,
pubmed-meshheading:20809970-Cross-Sectional Studies,
pubmed-meshheading:20809970-DNA, Neoplasm,
pubmed-meshheading:20809970-DNA Methylation,
pubmed-meshheading:20809970-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:20809970-Female,
pubmed-meshheading:20809970-Fluorouracil,
pubmed-meshheading:20809970-Gastrointestinal Neoplasms,
pubmed-meshheading:20809970-Gene Rearrangement,
pubmed-meshheading:20809970-Humans,
pubmed-meshheading:20809970-Introns,
pubmed-meshheading:20809970-Male,
pubmed-meshheading:20809970-Middle Aged,
pubmed-meshheading:20809970-Mucositis,
pubmed-meshheading:20809970-Mutation,
pubmed-meshheading:20809970-Neoplasm Staging,
pubmed-meshheading:20809970-Neutropenia,
pubmed-meshheading:20809970-Polymerase Chain Reaction,
pubmed-meshheading:20809970-Prognosis,
pubmed-meshheading:20809970-Promoter Regions, Genetic,
pubmed-meshheading:20809970-Survival Rate,
pubmed-meshheading:20809970-Thrombocytopenia
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients.
|
|
pubmed:affiliation |
Department of Medical Oncology, Portuguese Oncology Institute - Porto, Portugal.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
