Linked Life Data

20809776

Source:http://linkedlifedata.com/resource/pubmed/id/20809776

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-11-11
pubmed:abstractText
Retinopathy of Prematurity (ROP) is a vasoproliferative disorder affecting preterm infants leading to visual impairment. ROP is more common in Caucasians than African Americans. Very low birth weight infants have immature retinas and are susceptible to ROP. Because of differences in individual responses to the treatment, various genetic factors have been looked into to understand the etiology of ROP. Endothelial nitric oxide (eNO) serves as a vasodilator, relaxes smooth muscle, prevents platelet aggregation, and facilitates improved blood flow and vascular tonicity. Mutant eNO synthase (eNOS) genotypes result in reduced nitric oxide levels by decreasing enzyme activity. Since eNO affects vasculature and ROP is a vascular disease, the present investigation was aimed at studying the association of genotypes with ROP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1744-5094
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Endothelial nitric oxide synthase genotypes in the etiology of retinopathy of prematurity in premature infants.
pubmed:affiliation
Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA. kyanam@lsuhsc.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't