Linked Life Data

20809016

Source:http://linkedlifedata.com/resource/pubmed/id/20809016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-9-2
pubmed:abstractText
Similar to normal organs arising from normal stem cells, cancers can be viewed as organs composed of heterogeneous cellular populations arising from cancer cells with indefinite proliferation abilities. The continuous malignant progression is maintained by the proliferation of cancer stem cells and not the progeny that undergo limited proliferation before terminally differentiating. Effective therapy must eradicate malignant cells with unlimited clonogenic expansion within the primary tumor bulk. Thus, resolving both the specific cell of origin for prostate cancer and the interactions between the cells and the surrounding microenvironment within the cancer stem cell niche are crucial to appropriately define rational targets for therapeutic intervention and cure prostate cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1220-0522
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
427-35
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Cellular interactions in prostate cancer genesis and dissemination. Looking beyond the obvious.
pubmed:affiliation
Department of Cancer Immunology, Ion Chiricuta Comprehensive Cancer Center, Cluj-Napoca, Romania. ciprian.tomuleasa@gmail.com
pubmed:publicationType
Journal Article, Review