Linked Life Data

20807644

Source:http://linkedlifedata.com/resource/pubmed/id/20807644

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-9-2
pubmed:abstractText
Development of the mammalian central nervous system proceeds roughly in four major steps, namely the patterning of the neural tube, generation of neurons from neural stem cells and their migration to genetically predetermined destinations, extension of axons and dendrites toward target neurons to form neural circuits, and formation of synaptic contacts. Earlier studies on spatiotemporal expression patterns and in vitro function of heparan sulfate (HS) suggested that HS is functionally involved in various aspects of neural development. Recent studies using knockout of genes involved in HS biosynthesis have provided more physiologically relevant information as to the role of HS in mammalian neural development. This chapter reviews the current understanding of the in vivo function of HS deduced from the phenotypes of conditional Ext1 knockout mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1877-1173
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-52
pubmed:dateRevised
2011-6-15
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studies.
pubmed:affiliation
Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA.
pubmed:publicationType
Journal Article, Review