20807070

Source:http://linkedlifedata.com/resource/pubmed/id/20807070

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012634, umls-concept:C0038402, umls-concept:C0040517, umls-concept:C0332281, umls-concept:C0439780, umls-concept:C0439849, umls-concept:C0443146, umls-concept:C0445223, umls-concept:C1512653, umls-concept:C1521725, umls-concept:C1552599, umls-concept:C1704787
pubmed:issue	4
pubmed:dateCreated	2010-9-2
pubmed:abstractText	Obsessive-compulsive disorder (OCD) and related conditions including Tourette's disorder (TD) are chronic, relapsing disorders of unknown etiology associated with marked impairment and disability. Associated immune dysfunction has been reported and debated in the literature since the late 80s. The immunologic culprit receiving the most interest has been Group A Streptococcus (GAS), which began to receive attention as a potential cause of neuropsychiatric symptoms, following the investigation of the symptoms reported in Sydenham's chorea (SC) and rheumatic fever, such as motor tics, vocal tics, and both obsessive-compulsive and attention deficit/hyperactivity symptoms. Young children have been described as having a sudden onset of these neuropsychiatric symptoms temporally associated with GAS, but without supporting evidence of rheumatic fever. This presentation of OCD and tics has been termed pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS). Of note, SC, OCD, and TD often begin in early childhood and share common anatomic areas--the basal ganglia of the brain and the related cortical and thalamic sites--adding support to the possibility that these disorders might share a common immunologic and/or genetic vulnerability. Relevant manuscripts were identified through searches of the PsycINFO and MedLine databases using the following keywords: OCD, immune, PANDAS, Sydenham chorea, Tourette's disorder Group A Streptococcus. Articles were also identified through reference lists from research articles and other materials on childhood OCD, PANDAS, and TD between 1966 and December 2010. Considering the overlap of clinical and neuroanatomic findings among these disorders, this review explores evidence regarding the immunobiology as well as the relevant clinical and therapeutic aspects of TD, OCD, and PANDAS.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9105358
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	1557-8992
pubmed:author	pubmed-author:KurlanRogerR, pubmed-author:LeckmanJamesJ, pubmed-author:MurphyTanya KTK
pubmed:issnType	Electronic
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	317-31
pubmed:meshHeading	pubmed-meshheading:20807070-Animals, pubmed-meshheading:20807070-Attention Deficit Disorder with Hyperactivity, pubmed-meshheading:20807070-Autoimmune Diseases of the Nervous System, pubmed-meshheading:20807070-Child, pubmed-meshheading:20807070-Humans, pubmed-meshheading:20807070-Obsessive-Compulsive Disorder, pubmed-meshheading:20807070-Streptococcal Infections, pubmed-meshheading:20807070-Tics, pubmed-meshheading:20807070-Tourette Syndrome
pubmed:year	2010
pubmed:articleTitle	The immunobiology of Tourette's disorder, pediatric autoimmune neuropsychiatric disorders associated with Streptococcus, and related disorders: a way forward.
pubmed:affiliation	Department of Pediatrics and Psychiatry, University of South Florida, St Petersburg, Florida 33701, USA. tmurphy@health.usf.edu
pubmed:publicationType	Journal Article, Review