rdf:type |
|
lifeskim:mentions |
umls-concept:C0072899,
umls-concept:C0205314,
umls-concept:C0205549,
umls-concept:C0678594,
umls-concept:C0679622,
umls-concept:C1446409,
umls-concept:C1527178,
umls-concept:C1705938,
umls-concept:C1709060,
umls-concept:C1880355,
umls-concept:C2603343
|
pubmed:issue |
19
|
pubmed:dateCreated |
2010-9-13
|
pubmed:abstractText |
Starting from an HTS derived hit 1, application of biostructural data facilitated rapid optimization to lead 22, a novel AMPA receptor modulator. This is the first demonstration of how structure based drug design can be exploited in an optimization program for a glutamate receptor.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1464-3405
|
pubmed:author |
pubmed-author:BastenStephanieS,
pubmed-author:CampbellRobert ARA,
pubmed-author:CummingIain AIA,
pubmed-author:GillenKevin JKJ,
pubmed-author:GillespieJonathanJ,
pubmed-author:JamiesonCraigC,
pubmed-author:KazemierBertB,
pubmed-author:KiczunMichaelM,
pubmed-author:LamontYvonneY,
pubmed-author:LyonsAmanda JAJ,
pubmed-author:MacleanJohn K FJK,
pubmed-author:MoirElizabeth MEM,
pubmed-author:MorrowJohn AJA,
pubmed-author:PapakostaMarianthiM,
pubmed-author:RankovicZoranZ,
pubmed-author:UlsoyHH
|
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
|
pubmed:issnType |
Electronic
|
pubmed:day |
1
|
pubmed:volume |
20
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
5753-6
|
pubmed:meshHeading |
pubmed-meshheading:20805031-Allosteric Regulation,
pubmed-meshheading:20805031-Animals,
pubmed-meshheading:20805031-Binding Sites,
pubmed-meshheading:20805031-Crystallography, X-Ray,
pubmed-meshheading:20805031-Drug Design,
pubmed-meshheading:20805031-Drug Evaluation, Preclinical,
pubmed-meshheading:20805031-High-Throughput Screening Assays,
pubmed-meshheading:20805031-Humans,
pubmed-meshheading:20805031-Indazoles,
pubmed-meshheading:20805031-Microsomes,
pubmed-meshheading:20805031-Protein Structure, Tertiary,
pubmed-meshheading:20805031-Rats,
pubmed-meshheading:20805031-Receptors, AMPA,
pubmed-meshheading:20805031-Thiophenes
|
pubmed:year |
2010
|
pubmed:articleTitle |
A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies.
|
pubmed:affiliation |
Merck Research Laboratories, MSD, Motherwell, Lanarkshire ML1 5SH, UK.
|
pubmed:publicationType |
Journal Article
|