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rdf:type |
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lifeskim:mentions |
umls-concept:C0003374,
umls-concept:C0018966,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0048060,
umls-concept:C0220781,
umls-concept:C0314672,
umls-concept:C0441655,
umls-concept:C1441547,
umls-concept:C1883254,
umls-concept:C2603343
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pubmed:issue |
11
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pubmed:dateCreated |
2010-10-11
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pubmed:abstractText |
A new series of 4-aminoquinoline derivatives have been synthesized and found to be active against both susceptible and resistant strains of Plasmodium falciparum in vitro. Compound 1-[3-(7-chloro-quinolin-4-ylamino)-propyl]-3-cyclopropyl-thiourea (7) exhibited superior in vitro activity against resistant strains of P. falciparum as compared to chloroquine (CQ). All the compounds showed resistance factor between 0.59 and 4.31 as against 5.05 for CQ. Spectroscopic studies suggested that this class of compounds act on heme polymerization target.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1768-3254
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4990-6
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pubmed:meshHeading |
pubmed-meshheading:20805010-Aminoquinolines,
pubmed-meshheading:20805010-Animals,
pubmed-meshheading:20805010-Antimalarials,
pubmed-meshheading:20805010-Dose-Response Relationship, Drug,
pubmed-meshheading:20805010-Heme,
pubmed-meshheading:20805010-Magnetic Resonance Spectroscopy,
pubmed-meshheading:20805010-Plasmodium falciparum,
pubmed-meshheading:20805010-Polymers,
pubmed-meshheading:20805010-Spectrometry, Mass, Fast Atom Bombardment
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pubmed:year |
2010
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pubmed:articleTitle |
4-Aminoquinoline derived antimalarials: synthesis, antiplasmodial activity and heme polymerization inhibition studies.
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pubmed:affiliation |
Medicinal and Process Chemistry Division, Central Drug Research Institute, MG Road, Lucknow 226 001, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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