Linked Life Data

20804812

Source:http://linkedlifedata.com/resource/pubmed/id/20804812

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pubmed-article:20804812pubmed:abstractTextAcquired resistance to tamoxifen (TAM) is a serious therapeutic problem among breast cancer patients. Previously, we have reported that TAM-resistant MCF-7 cells (TAMR-MCF-7 cells) showed increased angiogenic intensity through Pin1-dependent vascular endothelial growth factor (VEGF) production. Among six flavonoids tested in the current study, VEGF gene transcription in MCF-7 cells with stable Pin1 overexpression was inhibited most effectively by quercetin. Reporter gene assays using minimal reporters containing hypoxia response elements and activator protein-1 (AP-1) elements revealed that the activities of hypoxia inducible factor-1? (HIF-1?) and AP-1, key transcription factors for VEGF gene transcription, were suppressed by quercetin. Western blot analyses confirmed that the increased nuclear levels of c-Jun and HIF-1? in TAMR-MCF-7 cells were blocked by quercetin. Moreover, quercetin inhibited the enhanced VEGF secretion and Pin1 expression in TAMR-MCF-7 cells, which was dependent on its phosphatidyl inositol 3-kinase inhibiting effect. Chick chorioallantoic membrane assays demonstrated that the enhanced angiogenesis intensity of TAMR-MCF-7 cells was also suppressed significantly by quercetin. These results demonstrate that quercetin may have therapeutic potential for the treatment of TAM-resistant breast cancer via Pin1 inhibition.lld:pubmed
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pubmed-article:20804812pubmed:authorpubmed-author:KimMi RaMRlld:pubmed
pubmed-article:20804812pubmed:authorpubmed-author:LeeJong SukJSlld:pubmed
pubmed-article:20804812pubmed:authorpubmed-author:OhSoo JinSJlld:pubmed
pubmed-article:20804812pubmed:authorpubmed-author:ShimJeong-Hyu...lld:pubmed
pubmed-article:20804812pubmed:copyrightInfoCopyright © 2010 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:20804812pubmed:articleTitleInhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells.lld:pubmed
pubmed-article:20804812pubmed:affiliationCollege of Pharmacy, Seoul National University, Seoul, Republic of Korea.lld:pubmed
pubmed-article:20804812pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20804812pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed