Source:http://linkedlifedata.com/resource/pubmed/id/20802161
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-10-13
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| pubmed:abstractText |
We determined the contribution of the combination of FEN1 10154G>T with the most significant association in the analysis of plasma arachidonic acid (AA, 20:4?6) and the APOA5-1131T>C on phospholipid ?6PUFA and coronary artery disease (CAD). Patients with CAD (n = 807, 27-81 years of age) and healthy controls (n = 1123) were genotyped for FEN1 10154G>T and APOA5-1131T>C. We found a significant interaction between these two genes for CAD risk (P = 0.007) adjusted for confounding factors. APOA5-1131C allele carriers had a higher CAD risk [odds ratio (OR):1.484, 95% confidence interval (CI):1.31-1.96; P = 0.005] compared with APOA5-1131TT individuals in the FEN1 10154GG genotype group but not in the FEN1 10154T allele group (OR:1.096, 95%CI:0.84-1.43; P = 0.504). Significant interactions between these two genes were also observed for the AA proportion (P = 0.04) and the ratio of AA/linoleic acid (LA, 18:2?6) (P = 0.004) in serum phospholipids of controls. The APOA5-1131C allele was associated with lower AA (P = 0.027) and AA/LA (P = 0.014) only in controls carrying the FEN1 10154T allele. In conclusion, the interaction between these genes suggests that the FEN1 10154T variant allele decreases AA and AA/LA in the serum phospholipids of carriers of the APOA5-1131C allele, but contributes no significant increase in CAD risk for this population subset despite their increased triglylcerides and decreased apoA5.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/APOA5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins A,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-6,
http://linkedlifedata.com/resource/pubmed/chemical/Flap Endonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid Peroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0022-2275
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
51
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3281-8
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| pubmed:dateRevised |
2011-11-1
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| pubmed:meshHeading |
pubmed-meshheading:20802161-Adult,
pubmed-meshheading:20802161-Aged,
pubmed-meshheading:20802161-Aged, 80 and over,
pubmed-meshheading:20802161-Apolipoproteins A,
pubmed-meshheading:20802161-Arachidonic Acids,
pubmed-meshheading:20802161-Case-Control Studies,
pubmed-meshheading:20802161-Coronary Artery Disease,
pubmed-meshheading:20802161-Fatty Acids, Omega-6,
pubmed-meshheading:20802161-Female,
pubmed-meshheading:20802161-Flap Endonucleases,
pubmed-meshheading:20802161-Humans,
pubmed-meshheading:20802161-Lipid Peroxides,
pubmed-meshheading:20802161-Lipoproteins, LDL,
pubmed-meshheading:20802161-Male,
pubmed-meshheading:20802161-Middle Aged,
pubmed-meshheading:20802161-Particle Size,
pubmed-meshheading:20802161-Phospholipids,
pubmed-meshheading:20802161-Polymorphism, Single Nucleotide,
pubmed-meshheading:20802161-Tumor Necrosis Factor-alpha
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| pubmed:year |
2010
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| pubmed:articleTitle |
Interactions between the APOA5 -1131T>C and the FEN1 10154G>T polymorphisms on ?6 polyunsaturated fatty acids in serum phospholipids and coronary artery disease.
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| pubmed:affiliation |
National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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