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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2010-9-20
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pubmed:abstractText |
Based on the well known biological versatility of the imidazoline nucleus, we prepared the novel derivatives 3a-k inspired by 2-BFI scaffold to assess imidazoline molecules as D(2)-like dopamine receptor ligands. Conservative chemical modifications of the lead structure, such as the introduction of an hydroxy group in the aromatic ring alone or associated with N-benzyl substitution, provided partial (3f) or nearly full (3e and 3h) agonists, all endowed with D(2)-like potency comparable to that of dopamine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:AmbrosiniDarioD,
pubmed-author:CarbonaraGiuseppeG,
pubmed-author:CarrieriAntonioA,
pubmed-author:CiampiOseleO,
pubmed-author:CostaBarbaraB,
pubmed-author:Di StefanoAntonioA,
pubmed-author:EnzenspergerChristophC,
pubmed-author:HudsonAlanA,
pubmed-author:MartiniClaudiaC,
pubmed-author:NasutiCinziaC,
pubmed-author:ParkJae-WonJW,
pubmed-author:PiginiMariaM,
pubmed-author:SozioPieraP,
pubmed-author:VespriniCristianC
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7085-91
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pubmed:meshHeading |
pubmed-meshheading:20801048-Animals,
pubmed-meshheading:20801048-Benzofurans,
pubmed-meshheading:20801048-Binding Sites,
pubmed-meshheading:20801048-Imidazoles,
pubmed-meshheading:20801048-Ligands,
pubmed-meshheading:20801048-Male,
pubmed-meshheading:20801048-Models, Molecular,
pubmed-meshheading:20801048-Molecular Structure,
pubmed-meshheading:20801048-Rats,
pubmed-meshheading:20801048-Rats, Wistar,
pubmed-meshheading:20801048-Receptors, Dopamine D2,
pubmed-meshheading:20801048-Stereoisomerism,
pubmed-meshheading:20801048-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI.
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pubmed:affiliation |
Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università degli Studi di Camerino, via Sant'Agostino 1, 62032 Camerino, Italy. gianfabio.giorgioni@unicam.it
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pubmed:publicationType |
Journal Article
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