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20801037
Source:
http://linkedlifedata.com/resource/pubmed/id/20801037
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0220781
,
umls-concept:C0243192
,
umls-concept:C0268563
,
umls-concept:C1417825
,
umls-concept:C1426330
,
umls-concept:C1883254
pubmed:issue
19
pubmed:dateCreated
2010-9-13
pubmed:abstractText
Optimization of a screening hit from uHTS led to the discovery of TGR5 agonist 32, which was shown to have activity in a rodent model for diabetes.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon-Like Peptide 1
,
http://linkedlifedata.com/resource/pubmed/chemical/Gpbar1 protein, mouse
,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyquinolines
,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolines
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled
,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes
,
http://linkedlifedata.com/resource/pubmed/chemical/quinoline
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1464-3405
pubmed:author
pubmed-author:AndersonJenniferJ
,
pubmed-author:BanerjeeUrmiU
,
pubmed-author:BischoffEricE
,
pubmed-author:CayananCharmagneC
,
pubmed-author:CokJ WJW
,
pubmed-author:DhamijaSangeetaS
,
pubmed-author:GuhaMausumeeM
,
pubmed-author:HerbertMark RMR
,
pubmed-author:HeymanRichard ARA
,
pubmed-author:KabakibiAymanA
,
pubmed-author:NobleStewart ASA
,
pubmed-author:PinkertonAnthony BAB
,
pubmed-author:RaoTadimeti STS
,
pubmed-author:RixPeterP
,
pubmed-author:ShiauAndrew KAK
,
pubmed-author:SiegelDana LDL
,
pubmed-author:StaszewskiLenaL
,
pubmed-author:WangLiL
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5718-21
pubmed:meshHeading
pubmed-meshheading:20801037-Animals
,
pubmed-meshheading:20801037-Diabetes Mellitus, Type 2
,
pubmed-meshheading:20801037-Glucagon-Like Peptide 1
,
pubmed-meshheading:20801037-Hydroxyquinolines
,
pubmed-meshheading:20801037-Mice
,
pubmed-meshheading:20801037-Quinolines
,
pubmed-meshheading:20801037-Receptors, G-Protein-Coupled
,
pubmed-meshheading:20801037-Structure-Activity Relationship
,
pubmed-meshheading:20801037-Thiophenes
pubmed:year
2010
pubmed:articleTitle
Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.
pubmed:affiliation
Department of Chemistry, Kalypsys, Inc.,10420 Wateridge Circle, San Diego, CA 92121, USA.
pubmed:publicationType
Journal Article