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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-11-2
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pubmed:abstractText |
Co-amoxiclav is one of the most common causes of drug-induced liver injury (DILI). Although there are previous reports of genetic associations between HLA class II and co-amoxiclav-related DILI, studies to date have been based on very small numbers from single centres only. In order to address this problem we have investigated the role of HLA class II DRB1 and DQB1 in 61 cases of co-amoxiclav DILI as part of a UK-wide multicentre study.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1049-53
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20800921-Aged,
pubmed-meshheading:20800921-Alleles,
pubmed-meshheading:20800921-Amoxicillin-Potassium Clavulanate Combination,
pubmed-meshheading:20800921-Anti-Bacterial Agents,
pubmed-meshheading:20800921-Case-Control Studies,
pubmed-meshheading:20800921-Cohort Studies,
pubmed-meshheading:20800921-Drug-Induced Liver Injury,
pubmed-meshheading:20800921-Female,
pubmed-meshheading:20800921-Genes, MHC Class II,
pubmed-meshheading:20800921-Genetic Predisposition to Disease,
pubmed-meshheading:20800921-Genotype,
pubmed-meshheading:20800921-HLA-DQ Antigens,
pubmed-meshheading:20800921-HLA-DQ beta-Chains,
pubmed-meshheading:20800921-HLA-DR Antigens,
pubmed-meshheading:20800921-HLA-DRB1 Chains,
pubmed-meshheading:20800921-Humans,
pubmed-meshheading:20800921-Male,
pubmed-meshheading:20800921-Middle Aged,
pubmed-meshheading:20800921-Risk Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury.
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pubmed:affiliation |
Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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