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rdf:type |
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lifeskim:mentions |
umls-concept:C0024501,
umls-concept:C0030956,
umls-concept:C0162741,
umls-concept:C0242726,
umls-concept:C1327616,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1710082,
umls-concept:C2350292
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pubmed:issue |
5995
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pubmed:dateCreated |
2010-8-27
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pubmed:abstractText |
Stem cells are maintained in the niche by intercellular interactions and signaling networks. In this work, we study extracellular signals required for maintenance of the root stem cell niche in higher plants. We identify a family of functionally redundant homologous peptides that are secreted, tyrosine-sulfated, and expressed mainly in the stem cell area and the innermost layer of central columella cells. We name these peptides root meristem growth factors (RGFs). RGFs are required for maintenance of the root stem cell niche and transit amplifying cell proliferation in Arabidopsis. RGF1 defines expression levels and patterns of the stem cell transcription factor PLETHORA, mainly at the posttranscriptional level. The RGFs function independently of the auxin pathway. These peptide signals play a crucial role in postembryonic root development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Indoleacetic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/PLT1 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/PLT2 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Growth Regulators,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfotransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/protein-tyrosine sulfotransferase
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
329
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1065-7
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pubmed:meshHeading |
pubmed-meshheading:20798316-Arabidopsis,
pubmed-meshheading:20798316-Arabidopsis Proteins,
pubmed-meshheading:20798316-Cell Proliferation,
pubmed-meshheading:20798316-Gene Expression Regulation, Plant,
pubmed-meshheading:20798316-Genes, Plant,
pubmed-meshheading:20798316-Indoleacetic Acids,
pubmed-meshheading:20798316-Meristem,
pubmed-meshheading:20798316-Peptides,
pubmed-meshheading:20798316-Phenotype,
pubmed-meshheading:20798316-Plant Growth Regulators,
pubmed-meshheading:20798316-Plant Roots,
pubmed-meshheading:20798316-Plants, Genetically Modified,
pubmed-meshheading:20798316-Recombinant Fusion Proteins,
pubmed-meshheading:20798316-Signal Transduction,
pubmed-meshheading:20798316-Stem Cell Niche,
pubmed-meshheading:20798316-Stem Cells,
pubmed-meshheading:20798316-Sulfotransferases,
pubmed-meshheading:20798316-Transcription Factors,
pubmed-meshheading:20798316-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis.
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pubmed:affiliation |
Graduate School of Bio-Agricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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