Linked Life Data

20797765

Source:http://linkedlifedata.com/resource/pubmed/id/20797765

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-9-20
pubmed:abstractText
A congener profile of polychlorinated dibenzo-p-dioxin and dibenzofurans (PCDD/Fs) could provide valuable information for identifying possible sources of exposure to these compounds. The purpose of this study is to identify factors associated with PCDD/F congener profiles in the general population of Taiwan. Serum samples from 251 subjects of the general population in Taiwan were collected, and the levels of 17 2,3,7,8-chlorinated substituted PCDD/Fs were measured. The relationships between PCDD/F congener profiles and demographic parameters were evaluated using a multivariate analysis of variance method (MANOVA). Of the five demographic factors investigated, age was found to have the greatest impact on PCDD/F congener profiles. The PCDD/F congener pattern for the group I subjects (aged 18-29) was significantly different from those for the other three older age groups (p<0.001), and 12 congeners contributed to the effects (difference index: 71%). In addition, the group I subjects did not exhibit trends parallel to those of the other groups in the relationship between age and PCDD/F levels. Age was associated with PCDD/F levels and congener profiles in the general population of Taiwan and the young subjects (aged 18-29) was quite different from the other older subjects that could be influenced by the individual differences in pharmacokinetics and/or background exposure from dietary sources. We conclude that investigators must consider subjects' age and other underlying factors that could influence PCDD/F congener profiles in humans when identifying exposure sources.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1879-1298
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
469-77
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Age-dependent congener profiles of polychlorinated dibenzo-p-dioxins and dibenzofurans in the general population of Taiwan.
pubmed:affiliation
Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 704, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't