| pubmed-article:20797753 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20797753 | lifeskim:mentions | umls-concept:C1622968 | lld:lifeskim |
| pubmed-article:20797753 | lifeskim:mentions | umls-concept:C0278996 | lld:lifeskim |
| pubmed-article:20797753 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20797753 | lifeskim:mentions | umls-concept:C0029005 | lld:lifeskim |
| pubmed-article:20797753 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:20797753 | lifeskim:mentions | umls-concept:C1524003 | lld:lifeskim |
| pubmed-article:20797753 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20797753 | pubmed:dateCreated | 2010-9-27 | lld:pubmed |
| pubmed-article:20797753 | pubmed:abstractText | High-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers, and they are also linked etiologically to a subset of head and neck squamous cell carcinomas (HNSCC). We previously established a model for HPV-associated HNSCC in which we treated transgenic mice expressing the papillomaviral oncoproteins with the chemical carcinogen 4-nitroquinoline-1-oxide (4-NQO). We found that the HPV-16 E7 oncoprotein was highly potent in causing HNSCC, and its dominance masked any potential oncogenic contribution of E6, a second papillomaviral oncoprotein commonly expressed in human cancers. In the current study, we shortened the duration of treatment with 4-NQO to reduce the incidence of cancers and discovered a striking synergy between E6 and E7 in causing HNSCC. Comparing the oncogenic properties of wild-type versus mutant E6 genes in this model for HNSCC uncovered a role for some but not other cellular targets of E6 previously shown to contribute to cervical cancer. | lld:pubmed |
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| pubmed-article:20797753 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20797753 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797753 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20797753 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20797753 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20797753 | pubmed:issn | 1096-0341 | lld:pubmed |
| pubmed-article:20797753 | pubmed:author | pubmed-author:LambertPaul... | lld:pubmed |
| pubmed-article:20797753 | pubmed:author | pubmed-author:PitotHenry... | lld:pubmed |
| pubmed-article:20797753 | pubmed:author | pubmed-author:JabbarSeanS | lld:pubmed |
| pubmed-article:20797753 | pubmed:author | pubmed-author:StratiKaterin... | lld:pubmed |
| pubmed-article:20797753 | pubmed:author | pubmed-author:ShinMyeong... | lld:pubmed |
| pubmed-article:20797753 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20797753 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20797753 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:20797753 | pubmed:volume | 407 | lld:pubmed |
| pubmed-article:20797753 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20797753 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20797753 | pubmed:pagination | 60-7 | lld:pubmed |
| pubmed-article:20797753 | pubmed:dateRevised | 2011-11-10 | lld:pubmed |
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| pubmed-article:20797753 | pubmed:meshHeading | pubmed-meshheading:20797753... | lld:pubmed |
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| pubmed-article:20797753 | pubmed:meshHeading | pubmed-meshheading:20797753... | lld:pubmed |
| pubmed-article:20797753 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20797753 | pubmed:articleTitle | Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice. | lld:pubmed |
| pubmed-article:20797753 | pubmed:affiliation | McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1400 University Avenue, Madison, WI 53706, USA. | lld:pubmed |
| pubmed-article:20797753 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20797753 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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