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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-9-27
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pubmed:abstractText |
High-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers, and they are also linked etiologically to a subset of head and neck squamous cell carcinomas (HNSCC). We previously established a model for HPV-associated HNSCC in which we treated transgenic mice expressing the papillomaviral oncoproteins with the chemical carcinogen 4-nitroquinoline-1-oxide (4-NQO). We found that the HPV-16 E7 oncoprotein was highly potent in causing HNSCC, and its dominance masked any potential oncogenic contribution of E6, a second papillomaviral oncoprotein commonly expressed in human cancers. In the current study, we shortened the duration of treatment with 4-NQO to reduce the incidence of cancers and discovered a striking synergy between E6 and E7 in causing HNSCC. Comparing the oncogenic properties of wild-type versus mutant E6 genes in this model for HNSCC uncovered a role for some but not other cellular targets of E6 previously shown to contribute to cervical cancer.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/CA098428,
http://linkedlifedata.com/resource/pubmed/grant/DE017315,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA098428-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA098428-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA098428-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA098428-07,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA098428-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA098428-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 DE017315-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 DE017315-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 DE017315-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 DE017315-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 DE017315-05
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-Nitroquinoline-1-oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/E6 protein, Human papillomavirus...,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Papillomavirus E7 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors,
http://linkedlifedata.com/resource/pubmed/chemical/oncogene protein E7, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1096-0341
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
407
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
60-7
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pubmed:dateRevised |
2011-11-10
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pubmed:meshHeading |
pubmed-meshheading:20797753-4-Nitroquinoline-1-oxide,
pubmed-meshheading:20797753-Animals,
pubmed-meshheading:20797753-Carcinogens,
pubmed-meshheading:20797753-Disease Models, Animal,
pubmed-meshheading:20797753-Head and Neck Neoplasms,
pubmed-meshheading:20797753-Human papillomavirus 16,
pubmed-meshheading:20797753-Mice,
pubmed-meshheading:20797753-Mice, Transgenic,
pubmed-meshheading:20797753-Oncogene Proteins, Viral,
pubmed-meshheading:20797753-Papillomavirus E7 Proteins,
pubmed-meshheading:20797753-Papillomavirus Infections,
pubmed-meshheading:20797753-Repressor Proteins,
pubmed-meshheading:20797753-Virulence Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice.
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pubmed:affiliation |
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1400 University Avenue, Madison, WI 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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