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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-8-27
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pubmed:abstractText |
The complete removal of the cardiac sodium-calcium exchanger (NCX1) is associated with embryonic lethality, whereas its overexpression is linked to heart failure. To determine whether or not a reduced expression of NCX1 is compatible with normal heart structure and function, we studied 2 knockout (KO) mouse models with reduced levels of NCX1: a heterozygous global KO (HG-KO) with a 50% level of NCX1 expression in all myocytes, and a ventricular-specific KO (V-KO) with NCX1 expression in only 10% to 20% of the myocytes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-10845086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-10966823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-10967099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-11344090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-11861419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-11874986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-12106593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-14615493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-15052282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-15308581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-15336980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-15359083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-15917272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-15979918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-16179590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-16293789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-16314583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-16884172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-16943244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-17350036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-17446467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-17517353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-1832775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-18340010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-19829181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-6283349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-8062418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797603-9614485
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1532-8414
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
786-96
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20797603-Adrenergic beta-Agonists,
pubmed-meshheading:20797603-Analysis of Variance,
pubmed-meshheading:20797603-Animals,
pubmed-meshheading:20797603-Aorta,
pubmed-meshheading:20797603-Cardiac Output,
pubmed-meshheading:20797603-Disease Models, Animal,
pubmed-meshheading:20797603-Heart Failure,
pubmed-meshheading:20797603-Hemodynamics,
pubmed-meshheading:20797603-Isoproterenol,
pubmed-meshheading:20797603-Mice,
pubmed-meshheading:20797603-Mice, Knockout,
pubmed-meshheading:20797603-Models, Cardiovascular,
pubmed-meshheading:20797603-Myocardium,
pubmed-meshheading:20797603-Sodium-Calcium Exchanger
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pubmed:year |
2010
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pubmed:articleTitle |
Myocardial function with reduced expression of the sodium-calcium exchanger.
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pubmed:affiliation |
Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. mjordan@mednet.ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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