Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-8-27
pubmed:abstractText
DEET is the most widely used insect repellent worldwide. In Drosophila olfactory receptor neurons (ORNs), DEET is detected through a mechanism employing the olfactory receptor, OR83b. However, it is controversial as to whether ORNs respond directly to DEET or whether DEET blocks the response to attractive odors. Here, we showed that DEET suppressed feeding behavior in Drosophila, and this effect was mediated by gustatory receptor neurons (GRNs). DEET was potent in suppressing feeding as <0.1% DEET elicited aversive behavior. Inhibition of feeding required multiple gustatory receptors (GRs) expressed in inhibitory GRNs. DEET stimulated action potentials in GRNs that respond to aversive compounds, and this response was lost in the Gr32a, Gr33a, and Gr66a mutants. Since 0.02% DEET elicited action potentials, we conclude that DEET directly activates of GRNs. We suggest that the effectiveness of DEET in pest control owes to its dual action in inducing avoidance simultaneously via GRNs and ORNs.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-10194755, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-11222642, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-11291099, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-12362054, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-12838579, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-14608037, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-15202999, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-15210117, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-15339651, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-15759000, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-16415164, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-16979558, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-17108954, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-17167414, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-17360684, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-17506643, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-17988633, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-18272250, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-18339904, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-18641642, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-18711137, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-19246397, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-19660932, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-19765987, http://linkedlifedata.com/resource/pubmed/commentcorrection/20797533-9144202
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1097-4199
pubmed:author
pubmed:copyrightInfo
2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
26
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
555-61
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Avoiding DEET through insect gustatory receptors.
pubmed:affiliation
Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural