| pubmed-article:20797425 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C0081620 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C2698420 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C0018061 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C1335073 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C1417834 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C1417833 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20797425 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20797425 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:20797425 | pubmed:dateCreated | 2010-10-11 | lld:pubmed |
| pubmed-article:20797425 | pubmed:abstractText | Normal sexual development and reproductive function depend on precise temporal and quantitative expression of the pituitary gonadotropins, LH and FSH. LH?-subunit gene expression is achieved by transcription factors acting at highly conserved and closely spaced cis-elements in the proximal 200 base pairs of the promoter. We now demonstrate that LH? promoter activity is further regulated by the orphan nuclear receptors, chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and COUP-TFII). These data establish that COUP-TFs are expressed in primary pituitary gonadotropes and two gonadotrope-derived cell lines. COUP-TFs bind to two promoter regions in the LH? gene which overlap but are distinct from two previously defined cis-elements for another orphan nuclear receptor, steroidogenic factor-1 (SF-1). Transient transfection studies demonstrated that COUP-TFs stimulate LH? gene promoter activity in the absence of SF-1, but blunt SF-1-mediated stimulation of gene expression in a reporter construct containing both SF-1 cis-elements (GSEs). Evaluation of constructs containing mutations or truncations in the GSEs revealed a complex pattern of activation and inhibition by COUP-TF on this promoter, suggesting multiple mechanisms by which this factor modulates LH? gene expression. To our knowledge, these data are the first to demonstrate COUP-TF expression and function in pituitary gonadotropes. | lld:pubmed |
| pubmed-article:20797425 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20797425 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20797425 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20797425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20797425 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20797425 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:20797425 | pubmed:issn | 1872-8057 | lld:pubmed |
| pubmed-article:20797425 | pubmed:author | pubmed-author:ZhengWeimingW | lld:pubmed |
| pubmed-article:20797425 | pubmed:author | pubmed-author:KimJonathanJ | lld:pubmed |
| pubmed-article:20797425 | pubmed:author | pubmed-author:HalvorsonLisa... | lld:pubmed |
| pubmed-article:20797425 | pubmed:author | pubmed-author:HortonCheryl... | lld:pubmed |
| pubmed-article:20797425 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20797425 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20797425 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20797425 | pubmed:volume | 330 | lld:pubmed |
| pubmed-article:20797425 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20797425 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20797425 | pubmed:pagination | 59-71 | lld:pubmed |
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| pubmed-article:20797425 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20797425 | pubmed:articleTitle | The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LH? gene. | lld:pubmed |
| pubmed-article:20797425 | pubmed:affiliation | Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9032, USA. | lld:pubmed |
| pubmed-article:20797425 | pubmed:publicationType | Journal Article | lld:pubmed |
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