Linked Life Data

2077112

Source:http://linkedlifedata.com/resource/pubmed/id/2077112

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-4-24
pubmed:abstractText
Previous studies of Golgi-impregnated material demonstrated the vulnerability of the dendritic arbors of the CA1 pyramidal cells of the hippocampus and the Purkinje and granule cells of the cerebellum to perinatal exposure to ethanol. The purpose of this investigation was to determine whether the alterations seen in the Golgi material could be corroborated at the ultrastructural level, and to qualitatively survey the neuropil surrounding the affected neurons. Pregnant mice were maintained on either a chocolate-flavoured liquid diet containing 25% of its caloric value as ethanol (5.4% v/v) or a chow and water diet. The treatment period began on gestational day 12 and continued until postnatal day 7, at which time the ethanol-exposed animals were returned to a chow and water diet. Pups were killed on postnatal day 14, and the tissue was processed for ultrastructural and Golgi analysis. The results confirm our Golgi findings that ethanol severely compromises the dendritic arbor, and also indicate that ethanol exposure produces changes in the organization of the neurophil, as well as alterations in the organization of the perikaryal organelles, and glial swelling.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0300-4864
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
708-17
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effect of perinatal administration of ethanol on the CA1 pyramidal cell of the hippocampus and Purkinje cell of the cerebellum: an ultrastructural survey.
pubmed:affiliation
Department of Anatomy, L.S.U. Medical School, New Orleans 70112-1393.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't