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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-4-22
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pubmed:abstractText |
1. The exposure of rat isolated tracheal segment to the K(+)-channel inhibitor tetraethylammonium (TEA, 10 mM) for a period of 10-15 min generally produced little or no contractile response. 2. Cooling (10 C) provocation alone usually produced small (10 +/- 3% acetylcholine maximum) contractile responses. 3. In the presence of TEA (10 mM, 10-15 min exposure), rat trachea exhibited airway hyperreactivity to acetylcholine, 5-hydroxytryptamine (5-HT) and cooling. It also increased the peak tension induced by 5-HT. 4. TEA-induced airway hyperreactivity to cooling was significantly inhibited in Ca2(+)-free Krebs solution suggesting an important role for extracellular Ca2+ influx. 5. We conclude that the blockade of potassium channels with TEA induces non-specific airway hyperreactivity to cooling, 5-HT and acetylcholine in rat isolated tracheal segments.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-1003694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-1119583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-1142117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-2451965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-3207972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-3427280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-3594074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-3709669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-6267677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-6715730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2076475-6871547
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
541-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2076475-Acetylcholine,
pubmed-meshheading:2076475-Animals,
pubmed-meshheading:2076475-Calcium,
pubmed-meshheading:2076475-Male,
pubmed-meshheading:2076475-Muscle Contraction,
pubmed-meshheading:2076475-Potassium Channels,
pubmed-meshheading:2076475-Rats,
pubmed-meshheading:2076475-Rats, Inbred Strains,
pubmed-meshheading:2076475-Serotonin,
pubmed-meshheading:2076475-Tetraethylammonium,
pubmed-meshheading:2076475-Tetraethylammonium Compounds,
pubmed-meshheading:2076475-Trachea
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pubmed:year |
1990
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pubmed:articleTitle |
Induction of non-specific airway hyperreactivity by potassium channel blockade in rat isolated trachea.
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pubmed:affiliation |
Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, New Jersey 08512.
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pubmed:publicationType |
Journal Article,
In Vitro
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