Linked Life Data

2076192

Source:http://linkedlifedata.com/resource/pubmed/id/2076192

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-4-25
pubmed:abstractText
The cytotoxic effect of cobalamin (vitamin B12) on the growth of malignant and nonmalignant cell lines in culture has been examined. Among the four cobalamins studied, 5'-deoxyadenosylcobalamin, an enzymatically active derivative, was an effective cytotoxic agent. The data indicated that adenosylcobalamin seemed to act selectively on fast-growing malignant cells. Methylcobalamin was also effective at elevated concentrations. Cyanocobalamin was not toxic to all cell lines studied. Hydroxocobalamin at very high concentrations was able to slightly decrease growth of certain cell lines. The results support the hypothesis that the cytotoxic effect of cobalamin was associated with the metabolic activities of this vitamin at the cellular level. Also, cobalamin may be a potential antitumor agent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1015-2008
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
292-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Cytotoxic activity of cobalamin in cultured malignant and nonmalignant cells.
pubmed:affiliation
Linus Pauling Institute of Science and Medicine, Palo Alto, Calif.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't