Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-4-16
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Animals, Laboratory, http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraception Research, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Male, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive..., http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents--side effects, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/Genital Effects, Male, http://linkedlifedata.com/resource/pubmed/keyword/Genitalia, http://linkedlifedata.com/resource/pubmed/keyword/Genitalia, Male, http://linkedlifedata.com/resource/pubmed/keyword/Gossypol--pharmacodynamics, http://linkedlifedata.com/resource/pubmed/keyword/Gossypol--side effects, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology, http://linkedlifedata.com/resource/pubmed/keyword/Testis, http://linkedlifedata.com/resource/pubmed/keyword/Urogenital System
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0587-2421
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5-6
pubmed:dateRevised
2006-11-15
pubmed:otherAbstract
PIP: The male contraceptive gossypol was developed by Chinese workers and tested on 10,000 male volunteers over a period of 5-8 years. It was effective in 99.8% of the cases. It acts also as an antiviral and antifungal agent inhibiting Trypnosone and Plasmodium, which cause Chagas and malaria respectively. This study also supports the efficacy of gossypol. Cellular and molecular lesions in the testis occurred with gossypol. Animal models have shown spermatogenesis after drug withdrawal. Bonnet monkey results support significantly reduced fertility. In vivo and in vitro work has been conducted in order to isolate the differential effects of optical isomers. The current results of unwanted side effects are 1) failure of recovery of spermatogenesis, and 2) hypokalemia. An operational model of action of gossypol on the testis is under development.
pubmed:meshHeading
pubmed:articleTitle
Gossypol.
pubmed:affiliation
Department of Biophysics, Panjab University, Chandigarh, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't