Linked Life Data

2074256

Source:http://linkedlifedata.com/resource/pubmed/id/2074256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-4-15
pubmed:abstractText
The single-dose pharmacokinetics of cefodizime were studied in ten hospitalized children aged between two and 15 years and weighing 12.5-26.2 kg. Six subjects received the drug (25 mg/kg) im and four received it iv. Cefodizime concentrations in blood and urine (iv dosage only) sampled up to 12h post dose were measured by microbiological assay and pharmacokinetic parameters were derived on the basis of a two-compartment open model. Peak serum concentrations were 131 +/- 22.7 mg/l (15 min post iv dose) and 54.8 +/- 17.8 mg/l (60 min post im dose). Mean T1/2 beta were 1.9 +/- 0.13 h (iv) and 1.88 +/- 0.25 h (im). Mean AUCs were 217.2 +/- 37.9 mg.h/l (iv) and 150.85 +/- 22.98 mg.h/l (im). Mean volumes of distribution were 7.6 +/- 2.5 l (iv) and 7.9 +/- 1.41 (im). Twelve hours after the iv administration the cumulative urinary excretion was 78-87% of the dose. The pharmacokinetic behaviour of cefodizime in children is thus similar to that of other compounds in this class.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
26 Suppl C
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
The pharmacokinetics of cefodizime in children.
pubmed:affiliation
First Pediatric Department, Milan University, Italy.
pubmed:publicationType
Journal Article