Source:http://linkedlifedata.com/resource/pubmed/id/20739669
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2010-12-1
|
| pubmed:abstractText |
The developmental viability of the preimplantation embryo requires the successful formation of a cluster of pluripotent stem cells called the inner cell mass. Development is variably compromised by a range of exogenous stressors (including their production by assisted reproductive technologies). Inbred C57BL/6 strain embryos are particularly susceptible to the stresses associated with embryo culture, whereas hybrid embryos are more resistant, and this is accounted for in part by the overexpression of transformation-related protein 53 in cultured inbred embryos compared with similarly treated hybrid embryos or embryos not subjected to culture. We show here that this loss of viability is a consequence of the Trp53-dependent reduction in the capacity of blastocysts to form a proliferating inner cell mass. Formation of the trophectodermal line was not adversely affected by these stresses.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1529-7268
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
958-64
|
| pubmed:meshHeading |
pubmed-meshheading:20739669-Animals,
pubmed-meshheading:20739669-Blastocyst Inner Cell Mass,
pubmed-meshheading:20739669-Cell Count,
pubmed-meshheading:20739669-Cell Proliferation,
pubmed-meshheading:20739669-Crosses, Genetic,
pubmed-meshheading:20739669-Ectogenesis,
pubmed-meshheading:20739669-Embryo Culture Techniques,
pubmed-meshheading:20739669-Female,
pubmed-meshheading:20739669-Genotype,
pubmed-meshheading:20739669-Inbreeding,
pubmed-meshheading:20739669-Male,
pubmed-meshheading:20739669-Mice,
pubmed-meshheading:20739669-Mice, Inbred C57BL,
pubmed-meshheading:20739669-Mice, Inbred CBA,
pubmed-meshheading:20739669-Mice, Transgenic,
pubmed-meshheading:20739669-Reproductive Techniques, Assisted,
pubmed-meshheading:20739669-Tumor Suppressor Protein p53,
pubmed-meshheading:20739669-Zygote
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Transformation-related protein 53 expression in the early mouse embryo compromises preimplantation embryonic development by preventing the formation of a proliferating inner cell mass.
|
| pubmed:affiliation |
Sydney Centre for Developmental and Regenerative Medicine, University of Sydney, St. Leonards, New South Wales, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|