| pubmed-article:20739318 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20739318 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:20739318 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:20739318 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:20739318 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20739318 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20739318 | pubmed:issue | 1704 | lld:pubmed |
| pubmed-article:20739318 | pubmed:dateCreated | 2010-12-23 | lld:pubmed |
| pubmed-article:20739318 | pubmed:abstractText | Mating rate is a major determinant of female lifespan and fitness, and is predicted to optimize at an intermediate level, beyond which superfluous matings are costly. In female Drosophila melanogaster, nutrition is a key regulator of mating rate but the underlying mechanism is unknown. The evolutionarily conserved insulin/insulin-like growth factor-like signalling (IIS) pathway is responsive to nutrition, and regulates development, metabolism, stress resistance, fecundity and lifespan. Here we show that inhibition of IIS, by ablation of Drosophila insulin-like peptide (DILP)-producing median neurosecretory cells, knockout of dilp2, dilp3 or dilp5 genes, expression of a dominant-negative DILP-receptor (InR) transgene or knockout of Lnk, results in reduced female remating rates. IIS-mediated regulation of female remating can occur independent of virgin receptivity, developmental defects, reduced body size or fecundity, and the receipt of the female receptivity-inhibiting male sex peptide. Our results provide a likely mechanism by which females match remating rates to the perceived nutritional environment. The findings suggest that longevity-mediating genes could often have pleiotropic effects on remating rate. However, overexpression of the IIS-regulated transcription factor dFOXO in the fat body-which extends lifespan-does not affect remating rate. Thus, long life and reduced remating are not obligatorily coupled. | lld:pubmed |
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| pubmed-article:20739318 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20739318 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20739318 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20739318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20739318 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20739318 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20739318 | pubmed:issn | 1471-2954 | lld:pubmed |
| pubmed-article:20739318 | pubmed:author | pubmed-author:GrönkeSebasti... | lld:pubmed |
| pubmed-article:20739318 | pubmed:author | pubmed-author:PartridgeLind... | lld:pubmed |
| pubmed-article:20739318 | pubmed:author | pubmed-author:MartinezPedro... | lld:pubmed |
| pubmed-article:20739318 | pubmed:author | pubmed-author:CalboliFederi... | lld:pubmed |
| pubmed-article:20739318 | pubmed:author | pubmed-author:ChapmanTracey... | lld:pubmed |
| pubmed-article:20739318 | pubmed:author | pubmed-author:WigbyStuartS | lld:pubmed |
| pubmed-article:20739318 | pubmed:author | pubmed-author:SlackCathyC | lld:pubmed |
| pubmed-article:20739318 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20739318 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:20739318 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:20739318 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20739318 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20739318 | pubmed:pagination | 424-31 | lld:pubmed |
| pubmed-article:20739318 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
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| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
| pubmed-article:20739318 | pubmed:meshHeading | pubmed-meshheading:20739318... | lld:pubmed |
| pubmed-article:20739318 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20739318 | pubmed:articleTitle | Insulin signalling regulates remating in female Drosophila. | lld:pubmed |
| pubmed-article:20739318 | pubmed:affiliation | Institute of Healthy Ageing and , Department of Genetics, Evolution and Environment, University College London, UK. stuart.wigby@zoo.ox.ac.uk | lld:pubmed |
| pubmed-article:20739318 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20739318 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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