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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2010-12-7
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pubmed:abstractText |
MicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of approximately 60% of all human genes. They play important roles in numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing the expression of target genes. In this study, the authors demonstrated that miRNA-205 (miR-205) induced the expression the interleukin (IL) tumor suppressor genes IL24 and IL32 by targeting specific sites in their promoters.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5637-49
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pubmed:meshHeading |
pubmed-meshheading:20737563-Cell Line, Tumor,
pubmed-meshheading:20737563-Cell Survival,
pubmed-meshheading:20737563-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20737563-Genes, Tumor Suppressor,
pubmed-meshheading:20737563-Humans,
pubmed-meshheading:20737563-Interleukins,
pubmed-meshheading:20737563-Male,
pubmed-meshheading:20737563-MicroRNAs,
pubmed-meshheading:20737563-Neoplasm Invasiveness,
pubmed-meshheading:20737563-Promoter Regions, Genetic,
pubmed-meshheading:20737563-Prostatic Neoplasms,
pubmed-meshheading:20737563-Transcriptional Activation
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pubmed:year |
2010
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pubmed:articleTitle |
MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer.
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pubmed:affiliation |
Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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