Linked Life Data

20737414

Source:http://linkedlifedata.com/resource/pubmed/id/20737414

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-2-25
pubmed:abstractText
Dextromethorphan is widely used in over-the-counter cough and cold medications. Its efficacy and safety for infants and young children remains to be clarified. The present study was designed to use zebrafish as a model to investigate the potential toxicity of dextromethorphan during embryonic and larval development. Three sets of zebrafish embryos/larvae were exposed to dextromethorphan at 24, 48 and 72?h post fertilization (hpf), respectively, during the embryonic/larval development. Compared with the 48 and 72?hpf exposure sets, the embryos/larvae in the 24?hpf exposure set showed much higher mortality rates which increased in a dose-dependent manner. Bradycardia and reduced blood flow were observed for the embryos/larvae treated with increasing concentrations of dextromethorphan. Morphological effects of dextromethorphan exposure, including yolk sac and cardiac edema, craniofacial malformation, lordosis, non-inflated swim bladder and missing gill, were also more frequent and severe among zebrafish embryos/larvae exposed to dextromethorphan at 24?hpf. Whether the more frequent and severe developmental toxicity of dextromethorphan observed among the embryos/larvae in the 24?hpf exposure set, as compared with the 48 and 72?hpf exposure sets, is due to the developmental expression of the phase I and phase II enzymes involved in the metabolism of dextromethorphan remains to be clarified. A reverse transcription-polymerase chain reaction analysis, nevertheless, revealed developmental stage-dependent expression of mRNAs encoding SULT3 ST1 and SULT3 ST3, two enzymes previously shown to be capable of sulfating dextrorphan, an active metabolite of dextromethorphan.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1099-1263
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-63
pubmed:meshHeading
pubmed-meshheading:20737414-Animals, pubmed-meshheading:20737414-Antitussive Agents, pubmed-meshheading:20737414-Behavior, Animal, pubmed-meshheading:20737414-Bradycardia, pubmed-meshheading:20737414-Craniofacial Abnormalities, pubmed-meshheading:20737414-Dextromethorphan, pubmed-meshheading:20737414-Dose-Response Relationship, Drug, pubmed-meshheading:20737414-Edema, pubmed-meshheading:20737414-Edema, Cardiac, pubmed-meshheading:20737414-Embryo, Nonmammalian, pubmed-meshheading:20737414-Embryonic Development, pubmed-meshheading:20737414-Feeding Behavior, pubmed-meshheading:20737414-Gene Expression Regulation, Developmental, pubmed-meshheading:20737414-Larva, pubmed-meshheading:20737414-RNA, Messenger, pubmed-meshheading:20737414-Regional Blood Flow, pubmed-meshheading:20737414-Sulfotransferases, pubmed-meshheading:20737414-Teratogens, pubmed-meshheading:20737414-Yolk Sac, pubmed-meshheading:20737414-Zebrafish, pubmed-meshheading:20737414-Zebrafish Proteins
pubmed:year
2011
pubmed:articleTitle
Developmental toxicity of dextromethorphan in zebrafish embryos/larvae.
pubmed:affiliation
Department of Pharmacology, College of Pharmacy, The University of Toledo, Toledo, OH 43606 USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural