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pubmed-article:20736897pubmed:abstractTextWe have previously shown that intragraft CD20+ B cells are associated with acute cellular rejection (ACR) and allograft loss. Phosphorylation of S6 ribosomal protein, a downstream target of the PI3K/Akt/mTOR pathway, promotes growth and proliferation of cells and could identify metabolically active cells such as alloantibody secreting plasma cells. Because CD20+ lymphocytes can differentiate into CD138+ plasma cells, we aimed to identify functionally active plasma cells by using intragraft CD138 quantification and p-S6RP staining and correlate these results with allograft rejection, function, and survival.lld:pubmed
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pubmed-article:20736897pubmed:articleTitleSignificance of intragraft CD138+ lymphocytes and p-S6RP in pediatric kidney transplant biopsies.lld:pubmed
pubmed-article:20736897pubmed:affiliationMattel Children's Hospital UCLA, Division of Pediatric Nephrology, Los Angeles, CA, USA. etsai@mednet.ucla.edulld:pubmed
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