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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-10-21
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pubmed:abstractText |
We have previously shown that intragraft CD20+ B cells are associated with acute cellular rejection (ACR) and allograft loss. Phosphorylation of S6 ribosomal protein, a downstream target of the PI3K/Akt/mTOR pathway, promotes growth and proliferation of cells and could identify metabolically active cells such as alloantibody secreting plasma cells. Because CD20+ lymphocytes can differentiate into CD138+ plasma cells, we aimed to identify functionally active plasma cells by using intragraft CD138 quantification and p-S6RP staining and correlate these results with allograft rejection, function, and survival.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1534-6080
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
875-81
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:20736897-Adolescent,
pubmed-meshheading:20736897-Antigens, CD,
pubmed-meshheading:20736897-Antigens, CD20,
pubmed-meshheading:20736897-B-Lymphocytes,
pubmed-meshheading:20736897-Biopsy,
pubmed-meshheading:20736897-Cadaver,
pubmed-meshheading:20736897-Child,
pubmed-meshheading:20736897-Child, Preschool,
pubmed-meshheading:20736897-Creatinine,
pubmed-meshheading:20736897-Female,
pubmed-meshheading:20736897-Graft Rejection,
pubmed-meshheading:20736897-Graft Survival,
pubmed-meshheading:20736897-Humans,
pubmed-meshheading:20736897-Intraoperative Period,
pubmed-meshheading:20736897-Kidney Transplantation,
pubmed-meshheading:20736897-Living Donors,
pubmed-meshheading:20736897-Male,
pubmed-meshheading:20736897-Retrospective Studies,
pubmed-meshheading:20736897-Syndecan-1,
pubmed-meshheading:20736897-Tissue Donors,
pubmed-meshheading:20736897-Transplantation, Homologous,
pubmed-meshheading:20736897-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Significance of intragraft CD138+ lymphocytes and p-S6RP in pediatric kidney transplant biopsies.
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pubmed:affiliation |
Mattel Children's Hospital UCLA, Division of Pediatric Nephrology, Los Angeles, CA, USA. etsai@mednet.ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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