Linked Life Data

20735837

Source:http://linkedlifedata.com/resource/pubmed/id/20735837

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-9-10
pubmed:abstractText
The mechanisms responsible for the cardiovascular mortality in type I diabetes (DM) have not been defined completely. We have shown in conscious dogs with DM that: 1) baseline coronary blood flow (CBF) was significantly decreased, 2) endothelium-dependent (ACh) coronary vasodilation was impaired, and 3) reflex cholinergic NO-dependent coronary vasodilation was selectively depressed. The most likely mechanism responsible for the depressed reflex cholinergic NO-dependent coronary vasodilation was the decreased bioactivity of NO from the vascular endothelium. The goal of this study was to investigate changes in cardiac gene expression in a canine model of alloxan-induced type 1 diabetes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1475-2840
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Oxidant-NO dependent gene regulation in dogs with type I diabetes: impact on cardiac function and metabolism.
pubmed:affiliation
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA. caroline_ojaimi@nymc.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural