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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2010-9-6
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pubmed:abstractText |
A series of 2,5-diaryloxadiazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates have been prepared and evaluated for their anticancer activity. These conjugates have shown promising activity with GI50 values ranging from <0.1 to 0.29 microM. It is observed that some of these conjugates particularly 4a, 4d, 4i and 4l exhibit significant anticancer activity. Some detailed biological assays relating to the cell cycle aspects associated to Bax and caspases have been examined with a view to understand the mechanism of action of these conjugates.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:BalakishanGG,
pubmed-author:BharathiE VijayaEV,
pubmed-author:DastagiriDD,
pubmed-author:JuvekarAartiA,
pubmed-author:KamalAhmedA,
pubmed-author:Pal-BhadraManikaM,
pubmed-author:PushpavalliS N C V LSN,
pubmed-author:RamaiahM JanakiMJ,
pubmed-author:ReddyJ SurendranadhaJS,
pubmed-author:SarmaPranjalP,
pubmed-author:SenSubrataS,
pubmed-author:ZingdeSurekhaS
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6666-77
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pubmed:meshHeading |
pubmed-meshheading:20732817-Animals,
pubmed-meshheading:20732817-Antineoplastic Agents,
pubmed-meshheading:20732817-Apoptosis,
pubmed-meshheading:20732817-Benzodiazepines,
pubmed-meshheading:20732817-Caspases,
pubmed-meshheading:20732817-Cell Cycle,
pubmed-meshheading:20732817-Cell Line, Tumor,
pubmed-meshheading:20732817-Cyclin-Dependent Kinase 2,
pubmed-meshheading:20732817-Humans,
pubmed-meshheading:20732817-Male,
pubmed-meshheading:20732817-Mice,
pubmed-meshheading:20732817-Mice, Inbred NOD,
pubmed-meshheading:20732817-Mitochondria,
pubmed-meshheading:20732817-Neoplasms,
pubmed-meshheading:20732817-Oxadiazoles,
pubmed-meshheading:20732817-Tumor Suppressor Protein p53,
pubmed-meshheading:20732817-Xenograft Model Antitumor Assays,
pubmed-meshheading:20732817-bcl-2-Associated X Protein
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pubmed:year |
2010
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pubmed:articleTitle |
Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates.
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pubmed:affiliation |
Chemical Biology Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India. ahmedkamal@iict.res.in
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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