Source:http://linkedlifedata.com/resource/pubmed/id/20732714
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-1-25
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| pubmed:abstractText |
In the present study, we analyzed AURKA and AURKB gene expression in 70 acute myeloid leukemia (AML) patients. There was no difference between leukemic samples and bone marrow mononuclear cells (BMMCs, n = 8) or CD34(+) progenitors (n = 10) from healthy donors. High white blood cells (WBC) counts were observed in the AURKA(+) and AURKB(+) groups, but no significant differences regarding age, gender, platelet counts or frequency of FLT3-ITD mutations. AURKA, but not AURKB, expression was independently associated with high WBC counts (OR: 3.15, 95%CI 1.07-9.24, p = 0.03). Moreover, the majority of cases that overexpressed AURKA and AURKB presented unfavorable cytogenetic abnormalities (p < 0.001). In conclusion, we described a significant association between overexpression of AURKA/B and cytogenetics findings in AML, which may be relevant to new therapeutic approaches, based on Aurora kinase inhibitors.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/FLT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/aurora kinase,
http://linkedlifedata.com/resource/pubmed/chemical/fms-Like Tyrosine Kinase 3
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1873-5835
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
35
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
260-4
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| pubmed:dateRevised |
2011-7-11
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| pubmed:meshHeading |
pubmed-meshheading:20732714-Adolescent,
pubmed-meshheading:20732714-Adult,
pubmed-meshheading:20732714-Aged,
pubmed-meshheading:20732714-Aged, 80 and over,
pubmed-meshheading:20732714-Child,
pubmed-meshheading:20732714-Child, Preschool,
pubmed-meshheading:20732714-Chromosome Aberrations,
pubmed-meshheading:20732714-Female,
pubmed-meshheading:20732714-Gene Expression Profiling,
pubmed-meshheading:20732714-Humans,
pubmed-meshheading:20732714-In Situ Hybridization, Fluorescence,
pubmed-meshheading:20732714-Leukemia, Myeloid, Acute,
pubmed-meshheading:20732714-Leukocyte Count,
pubmed-meshheading:20732714-Male,
pubmed-meshheading:20732714-Middle Aged,
pubmed-meshheading:20732714-Mutation,
pubmed-meshheading:20732714-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20732714-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20732714-Young Adult,
pubmed-meshheading:20732714-fms-Like Tyrosine Kinase 3
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| pubmed:year |
2011
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| pubmed:articleTitle |
High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia.
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| pubmed:affiliation |
Department of Internal Medicine, Hematology Division, National Institute of Science and Technology on Cell-Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, Av Bandeirantes 3900, 14048-900 Ribeirão Preto, Brazil.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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