Linked Life Data

20732385

Source:http://linkedlifedata.com/resource/pubmed/id/20732385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-9-27
pubmed:abstractText
Neuropsychological studies of the Wisconsin Card Sorting Test (WCST), where the WCST was administered to patients without prior knowledge of the test, have revealed that the performance is impaired by lesions to the dorsolateral and medial prefrontal cortex. The aim of this functional magnetic resonance imaging (fMRI) study is to explore the brain activity related to shifting under novel situations by adopting a modified WCST. The order of the WCST dimensions was determined based on the subjects' own choice, whereby subjects were more likely to shift without prior attempt of shifting in a similar situation. The brain activity in the initial shifts under novel situations was contrasted with the brain activity in the subsequent shifts under less novel situations. The contrast revealed significant brain activity both in the dorsolateral and medial prefrontal regions. Moreover, the brain activity in the dorsolateral prefrontal region was significantly lower at the very first of the initial shifts, where inhibition of proactive interference was needed to a lesser degree, while the medial prefrontal region showed a constant activation level across the initial shifts. These results demonstrate the involvement of the medial prefrontal region in the shifting in the WCST, and suggest the differential roles of the dorsolateral and medial prefrontal regions during shifting under novel situations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1872-7972
pubmed:author
pubmed:copyrightInfo
2010 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
484
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
182-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Medial prefrontal activity during shifting under novel situations.
pubmed:affiliation
Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. konishi@m.u-tokyo.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't