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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-9-24
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pubmed:abstractText |
Aneurysmal subarachnoid hemorrhage (SAH) affects relatively young people and carries a poor prognosis with a case fatality rate of 35%. One of the major systemic complications associated with SAH is acute lung injury (ALI) which occurs in up to one-third of the patients and is associated with poor outcome. ALI in SAH may be predisposed by neurogenic pulmonary edema (NPE) and inflammatory mediators. The objective of this study was to assess the immunomodulatory effects of interferon-? (IFN-?) on inflammatory mediators in the lung after experimental SAH.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1466-609X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R157
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pubmed:meshHeading |
pubmed-meshheading:20731855-Acute Lung Injury,
pubmed-meshheading:20731855-Animals,
pubmed-meshheading:20731855-Chemokine CCL3,
pubmed-meshheading:20731855-Chemokine CXCL1,
pubmed-meshheading:20731855-E-Selectin,
pubmed-meshheading:20731855-Inflammation,
pubmed-meshheading:20731855-Intercellular Adhesion Molecule-1,
pubmed-meshheading:20731855-Interferon-beta,
pubmed-meshheading:20731855-Lung,
pubmed-meshheading:20731855-Male,
pubmed-meshheading:20731855-Neutrophil Infiltration,
pubmed-meshheading:20731855-Rats,
pubmed-meshheading:20731855-Rats, Wistar,
pubmed-meshheading:20731855-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20731855-Subarachnoid Hemorrhage,
pubmed-meshheading:20731855-Tumor Necrosis Factor-alpha,
pubmed-meshheading:20731855-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2010
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pubmed:articleTitle |
Interferon-? attenuates lung inflammation following experimental subarachnoid hemorrhage.
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pubmed:affiliation |
Department of Intensive Care Medicine, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands. p.m.cobelens@umcutrecht.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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