Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-9-15
pubmed:abstractText
To create a moist environment for rapid wound healing, a hydrosheet composed of alginate, chitin/chitosan, and fucoidan (ACF-HS) has been developed as a functional wound dressing. The aim of this study was to evaluate the accelerating effect of ACF-HS on wound healing for rat mitomycin C-treated healing-impaired wounds. Full-thickness skin defects were made on the back of rats and mitomycin C was applied onto the wound for 10 minutes to prepare a healing-impaired wound. After thoroughly washing out the mitomycin C, ACF-HS was applied to the healing-impaired wounds. The rats were later euthanized and histological sections of the wounds were prepared. The histological examinations showed significantly advanced granulation tissue and capillary formations in the healing-impaired wounds treated with ACF-HS on days 7 and 14, in comparison with that in alginate fiber (Kaltostat), hydrogel wound dressing (DuoACTIVE), and nontreatment (negative control). Furthermore, in cell culture studies, ACF-HS-absorbed serum and fibroblast growth factor-2 was found to be proliferative for fibroblasts and endothelial cells, respectively, and ACF-HS-absorbed serum was found to be chemoattractive for fibroblasts. However, our results may not be strictly comparable with general healing-impaired wound models in humans because of the cell damage by mitomycin C. In addition, more biocompatibility studies of fucoidan are essential due to the possibility of renal toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Alginates, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials, http://linkedlifedata.com/resource/pubmed/chemical/Chitin, http://linkedlifedata.com/resource/pubmed/chemical/Chitosan, http://linkedlifedata.com/resource/pubmed/chemical/Glucuronic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Hexuronic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Hydrogel, http://linkedlifedata.com/resource/pubmed/chemical/Mitomycin, http://linkedlifedata.com/resource/pubmed/chemical/Nucleic Acid Synthesis Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Sulfuric Acid Esters, http://linkedlifedata.com/resource/pubmed/chemical/alginic acid, http://linkedlifedata.com/resource/pubmed/chemical/fucoidan
pubmed:status
MEDLINE
pubmed:issn
1524-475X
pubmed:author
pubmed:copyrightInfo
© 2010 by the Wound Healing Society.
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
478-85
pubmed:meshHeading
pubmed-meshheading:20731799-Alginates, pubmed-meshheading:20731799-Animals, pubmed-meshheading:20731799-Antineoplastic Agents, pubmed-meshheading:20731799-Bandages, pubmed-meshheading:20731799-Biocompatible Materials, pubmed-meshheading:20731799-Cells, Cultured, pubmed-meshheading:20731799-Chitin, pubmed-meshheading:20731799-Chitosan, pubmed-meshheading:20731799-Dermis, pubmed-meshheading:20731799-Disease Models, Animal, pubmed-meshheading:20731799-Fibroblasts, pubmed-meshheading:20731799-Glucuronic Acid, pubmed-meshheading:20731799-Hexuronic Acids, pubmed-meshheading:20731799-Humans, pubmed-meshheading:20731799-Hydrogel, pubmed-meshheading:20731799-Male, pubmed-meshheading:20731799-Mitomycin, pubmed-meshheading:20731799-Nucleic Acid Synthesis Inhibitors, pubmed-meshheading:20731799-Polysaccharides, pubmed-meshheading:20731799-Rats, pubmed-meshheading:20731799-Rats, Sprague-Dawley, pubmed-meshheading:20731799-Skin, pubmed-meshheading:20731799-Sulfuric Acid Esters, pubmed-meshheading:20731799-Wound Healing, pubmed-meshheading:20731799-Wound Infection, pubmed-meshheading:20731799-Wounds and Injuries
pubmed:articleTitle
Enhanced healing of mitomycin C-treated healing-impaired wounds in rats with hydrosheets composed of chitin/chitosan, fucoidan, and alginate as wound dressings.
pubmed:affiliation
Department of Oral and Maxillofacial Surgery Research Institute, National Defense Medical College, Tokorozawa, Saitama, Japan. dr22056@ndmc.ac.jp
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't