Linked Life Data

20731671

Source:http://linkedlifedata.com/resource/pubmed/id/20731671

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-11-2
pubmed:abstractText
The transcription factor Fli-1 is implicated in the pathogenesis of both murine and human lupus. Increased levels of Fli-1 mRNA were present in the peripheral blood lymphocytes from lupus patients; furthermore, transgenic overexpression of Fli-1 in normal mice resulted in the development of a lupus-like disease. Lupus nephritis is a major cause of death in both lupus patients as well as in animal models. In this study, we generated Fli-1 heterozygous knockout (Fli-1(+/)? ) NZM2410 mice (of which the wild-type is a widely used lupus murine model) that expressed decreased levels of Fli-1 and investigated the impact of Fli-1 expression on lupus nephritis development and survival. Ninety-three per cent of the Fli-1(+/)? NZM2410 mice survived to the age of 52 weeks compared to only 35% of wild-type NZM2410 mice. Autoantibodies, including anti-dsDNA and anti-glomerular basement antigen, in Fli-1(+/)? NZM2410 mice were statistically significantly lower when compared to wild-type NZM2410 mice at the ages of 30 and 34 weeks. Total B cell and activated B cell populations in the spleens from Fli-1(+/)? NZM2410 mice were decreased significantly compared to wild-type NZM2410 mice. Fli-1(+/)? NZM2410 mice also had remarkably diminished proteinuria and decreased renal pathological scores when compared with wild-type NZM2410 mice. Expression of early growth response 1 (Egr-1) was decreased significantly in the kidneys from Fli-1(+/)? NZM2410 mice when compared to wild-type littermates. Our data indicate that expression of Fli-1 plays an important role in lupus disease development in NZM2410 mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1365-2249
pubmed:author
pubmed:copyrightInfo
© 2010 British Society for Immunology.
pubmed:issnType
Electronic
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
362-71
pubmed:dateRevised
2011-11-1
pubmed:meshHeading
pubmed-meshheading:20731671-Animals, pubmed-meshheading:20731671-Antibodies, Antinuclear, pubmed-meshheading:20731671-Antibody Formation, pubmed-meshheading:20731671-Autoantibodies, pubmed-meshheading:20731671-B-Lymphocytes, pubmed-meshheading:20731671-Cell Count, pubmed-meshheading:20731671-Early Growth Response Protein 1, pubmed-meshheading:20731671-Female, pubmed-meshheading:20731671-Gene Expression, pubmed-meshheading:20731671-Immunoglobulin G, pubmed-meshheading:20731671-Kidney, pubmed-meshheading:20731671-Lupus Nephritis, pubmed-meshheading:20731671-Male, pubmed-meshheading:20731671-Mice, pubmed-meshheading:20731671-Mice, Inbred MRL lpr, pubmed-meshheading:20731671-Mice, Knockout, pubmed-meshheading:20731671-Proteinuria, pubmed-meshheading:20731671-Proto-Oncogene Protein c-fli-1, pubmed-meshheading:20731671-Spleen, pubmed-meshheading:20731671-Survival Analysis, pubmed-meshheading:20731671-T-Lymphocytes
pubmed:year
2010
pubmed:articleTitle
Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 mice.
pubmed:affiliation
Department of Medicine, Medical University of South Carolina, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural