Linked Life Data

20731004

Source:http://linkedlifedata.com/resource/pubmed/id/20731004

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-8-23
pubmed:abstractText
Urinary cytology has a significant role in the detection and surveillance of patients with urothelial carcinoma (UC), which has a high morbidity rate in the United States. Examination of the urine is a comprehensive screen of both the upper and lower urinary tract and is ideal for detecting both primary bladder UC and synchronous or metachronous, multifocal UCs that commonly occur because of a "field effect." This field effect is the result of both clonal and random genetic abnormalities that have resulted from exposure to carcinogens (most frequently in tobacco smoke) in conjunction with the individual's ability to repair DNA damage. Although urinary cytology has high specificity for the detection of UC, its sensitivity is relatively low, especially for more prevalent low-grade tumors. Consequently, several urine-based tests have been investigated, some of which are available commercially and approved by the US Food and Drug Administration. However, these tests also have their limitations and often have lower specificity than urinary cytology. Consequently, urinary cytology, which is a noninvasive, cost-effective test, continues in mainstream use because of its ability to detect high-grade, flat lesions that can be difficult to detect clinically and that often have more aggressive biologic behavior.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1934-662X
pubmed:author
pubmed:copyrightInfo
(c) 2010 American Cancer Society.
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-83
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
A review on the current state of urine cytology emphasizing the role of fluorescence in situ hybridization as an adjunct to diagnosis.
pubmed:affiliation
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. ncaraway@mdanderson.org
pubmed:publicationType
Journal Article, Review