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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-9-7
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pubmed:abstractText |
The article by McConoughey et al in the current issue of EMBO Molecular Medicine examines the contribution of transglutaminase 2 (TG2) to Huntington's disease (HD) pathogenesis. The authors find that TG2 inhibition can ameliorate HD neurodegeneration, and thereby elevate the status of transglutaminases (TGs) to a major therapeutic target-not because of their well-known activity in mutant protein aggregation, but instead based upon their ability to epigenetically modulate transcription and energy production. While the reintroduction of TG inhibition as a therapy for HD may evoke feelings of déjà vu, the outcome this time around could go in a dramatically different direction.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1757-4684
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
335-7
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pubmed:meshHeading |
pubmed-meshheading:20730854-Animals,
pubmed-meshheading:20730854-Disease Models, Animal,
pubmed-meshheading:20730854-Drosophila,
pubmed-meshheading:20730854-Energy Metabolism,
pubmed-meshheading:20730854-Enzyme Inhibitors,
pubmed-meshheading:20730854-GTP-Binding Proteins,
pubmed-meshheading:20730854-Histones,
pubmed-meshheading:20730854-Humans,
pubmed-meshheading:20730854-Huntington Disease,
pubmed-meshheading:20730854-Peptides,
pubmed-meshheading:20730854-Polyamines,
pubmed-meshheading:20730854-Transcription, Genetic,
pubmed-meshheading:20730854-Transglutaminases
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pubmed:year |
2010
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pubmed:articleTitle |
Déjà vu with a twist: transglutaminases in bioenergetics and transcriptional dysfunction in Huntington's disease.
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pubmed:affiliation |
Division of Genetics, Department of Pediatrics, University of California, San Diego - La Jolla, CA, USA.
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pubmed:publicationType |
Journal Article,
Comment,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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