In this issue, Weber and coworkers report that DNA-demethylating drugs alter the transcriptional expression of the cMet proto-oncogene. Abnormal transcription is driven by the antisense promoter of a Line-1 repetitive element present within an intron. The element is a recent addition to the genome and is absent in animal models of cancer.
Department of Pathology, Interdepartmental Computational Biology & Bioinformatics Program, Yale University School of Medicine, New Haven, CT 06520, USA. paul.lizardi@mac.com